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Heidi Welch
Rac-GEF Signalling Group
The Babraham Institute
Babraham Research Campus
Cambridge CB22 3AT
UK
Tel: +44 1223 496 596
Fax: +44 1223 496 043
Email: heidi.welch@babraham.ac.uk
Websites: The Babraham Institute, Rac-GEF Signalling Group
Our group is part of the Signalling lab at the Babraham Institute. We are interested in activators of the small G protein Rac, an essential regulator of cell shape and motility, gene expression and reactive oxygen species formation. A few years ago, we discovered a new family of Rac activators, the P-Rex family of guanine-nucleotide exchange factors. Since then, we have been studying their functional importance and mode of regulation, concentrating mainly on two cell systems, neutrophils and the Purkinje neuron of the cerebellum.
