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Per-Arne Oldenborg

Per-Arne Oldenborg, PhD

Oldenborg Lab

Umeå University
Dept. of Integrative Medical Biology
Sect. for Histology and Cell Biology
SE-901 87 Umeå
Sweden
Phone: +4690-786 5974
Cellphone: +46730-548050
Fax: +4690-786 6696

Email: per-arne.oldenborg@histocel.umu.se

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Website: http://www.info.umu.se/FoDB/Projektbeskrivning.aspx?id=37

We have found that macrophages can discriminate between self and non-self, where “self” is represented by the ubiquitously expressed cell surface glycoprotein CD47. CD47 is expressed on virtually all cells in the host and can be recognized by the inhibitory receptor signal regulatory protein alpha (SIRPa) on phagocytes. This interaction can potently inhibit phagocytosis of IgG- or complement-opsonized host cells. Our current ongoing research serves to better understand how this inhibitory mechanism regulates uptake of viable or apoptotic cells, mediated by various pro-phagocytic receptors (e.g. FcgR, CR, scavenger receptors, etc.)
Other projects in the lab are focused on studying the role of CD47 and/or SIRPa in the regulation of neutrophil, DC, and lymphocyte activation, and osteoclast formation, both in vivo and in vitro.

Recent publications

  • Oldenborg, P.-A., Zheleznyak, A., Fang, Y.-F., Lagenaur, C.F., Gresham, H.D. and Lindberg, F.P. (2000) Role of CD47 as a marker of self on red blood cells. Science 288:2051-2054 [comments ibid 288:1945-1946].
  • Oldenborg, P.-A., Gresham, H.D. and Lindberg, F.P. (2001) CD47-signal regulatory protein alpha (SIRPa) regulates Fcg and complement receptor-mediated phagocytosis. J. Exp. Med. 193:855-861.
  • Olsson, M., Bruhns, P., Frazier, W.A., Ravetch, J.V., and Oldenborg P.-A. (2005) Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood, 105:3577-3582.
  • Gardai, S., McPhillips, K., Frasch, S.C., Starefeldt, A., Bratton,D.B., Oldenborg, P.-A., Michalak, M., and Henson, P.M. (2005) Cell surface calreticulin initiates clearance of viable or apoptotic cells through trans activation of LRP on the phagocyte. Cell 123:321-334.
  • Hagnerud, S., Manna, P. P., Cella, M., Stenberg, Å., Frazier, W.A., Colonna, M., and Oldenborg, P.-A. (2006) Deficit of CD47 results in a defect of marginal zone DC, blunted immune response to particulate antigen and impairment of skin DC migration. J. Immunol. 176:5772-5778.
  • Lundberg, P., Koskinen, C.,  Baldock, P.A., Löthgren, H., Stenberg, Å., Lerner, U.H. and Oldenborg, P.-A. (2007) Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPa-interaction. Biochem. Biophys. Res. Commun. 352: 444-448.
  • Olsson, M. and Oldenborg, P.-A. (2008) CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcg receptor-mediated but not scavenger receptor-mediated recognition by macrophages. Blood, prepublished online September 8, 2008; DOI 10.1182/blood-2008-03-143008.