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Dr Lars-Peter Erwig
Aberdeen University Phagocyte Lab
Division of Applied Medicine
School of Medicine and Dentistry
Institute of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
Tel : 01224 550526
Fax : 01224 555766
Email: l.p.erwig@abdn.ac.uk
Website: http://www.abdn.ac.uk/ims/immunology/research/renal_innate.php
Dr. Erwig has a longstanding interest in the role of macrophages in the progression and healing of inflammation. His initial work has focussed on the signals that activate macrophages in vitro and glomerulonephritis and he has developed the concept of macrophage programming to explain how macrophages function within inflamed or otherwise damaged tissue where they are exposed to complex environments. Our research group now focuses on the consequences of apoptotic cell and pathogen uptake for phagocyte function and in particular on how the digestion of ingested cells or pathogens is controlled within macrophage phagosomes. In addition, Dr Erwig has a strong clinical and research interest in multisystem diseases such as SLE and Wegener's Granulomatosis.
Candida escaping from macrophage
Publications:
Graham A, Ford I, Morisson R, Barker RN, Greaves M, Erwig LP. Autoantibody Interference in Apoptotic Cell Clearance Promotes Thrombosis in Antiphospholipid Syndrome. Journal of Immunology. 2009. In Press.
Erwig LP, Henson PM. Clearance of apoptotic cells by phagocytes. Cell Death Differ. 2008 Feb; 15(2):243-250.
Erwig LP, Henson PM. Immunological consequences of apoptotic cell phagocytosis. Am J Path. 2007 Jul;171(1):2-8.
Erwig LP, Kathleen A. McPhilips, Murray W. Wynes, Alexander Ivetic, Anne J. Ridley and Peter M. Henson. Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ERM proteins. Proc Natl Acad Sci USA. 2006 Aug 22;103(34):12825-30.
Minto AWM*, Erwig LP*, Rees AJ. Heterogeneity of macrophage activation in Anti-Thy-1.1 nephritis. Am J Path. 2003 Nov;163(5). *These Authors contributed equally to the work.
Barker RN*, Erwig LP*, Hill KS, Devine A, Pearce WP, Rees AJ. Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells. Clin Exp Immunol. 2002 Feb;127(2):220-5. *These authors contributed equally to the work.
Erwig LP, Stewart K, Rees AJ. Macrophages from inflamed but not normal glomeruli are unresponsive to anti-inflammatory cytokines. Am J Pathol. 2000 Jan;156(1):295-301.
Duffield JS, Erwig LP, Wei X, Liew FY, Rees AJ, Savill JS. Activated macrophages direct apoptosis and suppress mitosis of mesangial cells. J Immunol. 2000 Feb 15;164(4):2110-9.
Kluth DC, Erwig LP, Pearce WP, Rees AJ. Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus. Gene Ther. 2000 Feb;7(3):263-70.
Erwig LP, Gordon S, Walsh GM, Rees AJ. Previous uptake of apoptotic neutrophils or ligation of integrin receptors downmodulates the ability of macrophages to ingest apoptotic neutrophils. Blood. 1999 Feb 15;93(4):1406.
Erwig LP, Kluth DC, Walsh GM, Rees AJ. Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J Immunol. 1998 Aug 15;161(4):1983-8.