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Guy Brown PhD

Guy Brown, PhD

Brown Group

Department of Biochemistry
University of Cambridge
Hopkins Building
8 Tennis Ct Rd
Cambridge, CB2 1QW


Microglia are brain macrophages. We are trying to understand how microglia damage or protect neurons during neuroinflammation and brain pathologies, such as neurodegeneration.

We use mouse models of disease and cultured brain cells to investigate how microglia become activated by inflammatory stimuli, and how such microglia can damage or protect neurons. We are particularly interested in the roles of microglial phagocytosis in neurodegeneration, as we have found that inflamed microglia can phagocytose (i.e. eat) live neurons and neuronal parts such as synapses. And so we are trying to find ways to prevent this.

Want to know more?
Our research lab on microglia:
A website about microglia:
A European webinar series on microglia: